|
Xanthoma tendinosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX.
|
19448742 |
2009 |
|
Tumor thrombus
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
However, a stratified analysis revealed that high expression of CXCL3 was associated with considerably increased mortality in the subgroup of CC patients with tumor size <5 cm (adjusted P=0.042, adjusted HR=2.298, 95% CI=1.030‑5.126) and with tumor thrombus (adjusted P=0.019, adjusted HR=5.096, 95% CI=1.306‑19.886).
|
31545503 |
2019 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
These CD14(+) CD16(+) monocytes were suggested to enhance tumour progression as this subpopulation possesses (i) high expression of adhesion molecules (CD11c, CD49d, and CD54) and scavenger receptor (CD163), which enable them to adhere strongly to endothelial cells, and (ii) that peripheral blood monocytes from CCA patients express high levels of growth and angiogenic factor-related genes (epiregulin, VEGF-A and CXCL3).
|
20636398 |
2010 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, the CXCL3 function in HTR-8/Svneo was analyzed via WST-1 assay, flow cytometry and invasion test.
|
25485631 |
2014 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The result suggests that CXCL3 is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia.
|
29884302 |
2018 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Real-time PCR data demonstrated that baicalin attenuated increased proinflammatory cytokine (IL-1<i>β</i>, IL-6, and CXCL-3) production in subarachnoid hemorrhage mice.
|
28912935 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17 stimulated ESCC tumor cells to release more of the CXC chemokines CXCL2 and CXCL3, which are involved in neutrophil migration.
|
29296528 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of GRO-2 and GRO-3 was already enhanced in premalignant adenomas, and GRO-3 was significantly down-regulated in liver metastasis as compared to the primary tumor.
|
20162422 |
2010 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TNF-induced mRNA stabilization in RA FLS occurs during the late phase of TNF response, is MAPK-dependent, and involves several genes with pathogenic potential such as IL6, CXCL1, CXCL3, CXCL8/IL8, CCL2, and PTGS2.
|
28708839 |
2017 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, high-level CXCL3 can be secreted by PC-3 and RWPE-1, and CXCL3 protein expression level in tissue microarray is concordant with prostate cancer metastasis.
|
26837773 |
2016 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CXCL3 autocrine/paracrine pathways are involved in the development of prostate cancer by regulating the expression of the target genes that are related to the progression of malignancies.
|
29524043 |
2018 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy.
|
24605943 |
2014 |
|
Periapical Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant DNA hypermethylation was observed for CXCL3 and FADD gene promoters in AP lesions when compared to control tissues (P < 0.001) and among other genes (P < 0.05).
|
29904933 |
2019 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
These results provide novel insight into the crucial role of CXCR2 in neuropathy based on CXCL3 modulation, which may become a potential therapeutic target in pain treatment.
|
31616413 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Intrathecal administration of CXCL3 neutralizing antibody diminished neuropathic pain on day 7 after CCI.
|
31616413 |
2019 |
|
Nervous System, Organic Arsenic Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
KRAS<sup>∗</sup>-mediated repression of IRF2 results in high expression of CXCL3, which binds to CXCR2 on myeloid-derived suppressor cells and promotes their migration to the tumor microenvironment.
|
30905761 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We showed by microarray and by RT-PCR that NDRG3 overexpression up-regulates the expression of many angiogenic chemokines including CXCL1 (chemokine ligand 1), CXCL3 (chemokine ligand 3) and CXCL5 (chemokine ligand 5), which may increase angiogenesis of tumors.
|
18975380 |
2009 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Molecular and functional characterization of tumor-induced factor (TIF): Hamster homolog of CXCL3 (GRO<sub>γ</sub>) displays tumor suppressive activity.
|
29276973 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Expression of GRO-2 and GRO-3 was already enhanced in premalignant adenomas, and GRO-3 was significantly down-regulated in liver metastasis as compared to the primary tumor.
|
20162422 |
2010 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Reverse transcription‑quantitative PCR (RT‑qPCR) analysis of 38 paired tumor and non‑tumor tissues, and immunohistochemistry (IHC) of 212 tumor and 46 non‑tumor tissues was conducted to explore the expression of CXCL3 and its diagnostic and prognostic significance in the Guangxi Medical University CC cohort.
|
31545503 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
CCK-8, transwell assays and growth of tumor xenografts were conducted to characterize the effects of CXCL3 on PC-3 cells' proliferation and migration.
|
29524043 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, GRO-3 was related to metastasis formation, and IL-8 was associated with survival, suggesting a potential predictive power of these markers.
|
20162422 |
2010 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy.
|
24605943 |
2014 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, high-level CXCL3 can be secreted by PC-3 and RWPE-1, and CXCL3 protein expression level in tissue microarray is concordant with prostate cancer metastasis.
|
26837773 |
2016 |